• PMID: 23910090
• Gene Name: FAS
• Condition: Varicocele, Male infertility
• Association: Down regulation of seminal sFas in Vx associated men is related to increased oxidative stress and is correlated with Vx grade.
• Population size: 230
• Population details: 230 men were prospectively investigated: fertile men without Vx, fertile men with Vx, infertile men without Vx, and infertile men with Vx.
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Varicocele, Male infertility

Seminal soluble fas relationship with oxidative stress in infertile men with varicocele

Tawadrous GA, Aziz AA, Mostafa T.

OBJECTIVE: To assess seminal plasma soluble Fas (sFas) relationship with oxidative stress and varicocele (Vx) grade in infertile men. METHODS: In all, 230 men were prospectively investigated: fertile men without Vx, fertile men with Vx, infertile men without Vx, and infertile men with Vx. In their semen, seminal oxidant (malondialdehyde [MDA]), antioxidants (ascorbic acid, glutathione peroxidase [GPx], catalase [CAT], and superoxide dismutase [SOD]), and seminal sFas were assessed. RESULTS: Either fertile or infertile men with Vx demonstrated significantly higher seminal oxidants (MDA) and significantly lower seminal antioxidants (SOD, GPx, CAT, and ascorbic acid), sFas compared with fertile or infertile men without Vx. Infertile men with or without Vx had significantly higher seminal MDA and significantly lower seminal antioxidants, sFas compared with fertile men with or without Vx. Men with Vx grade III had significantly higher seminal MDA and significantly lower antioxidants, sFas compared with Vx grade II and I, respectively. Seminal sFas demonstrated significant positive correlation with sperm count, sperm motility, sperm normal forms, seminal ascorbic acid, SOD, GPx, and CAT and significant negative correlation with seminal MDA. CONCLUSION: Down regulation of seminal sFas in Vx associated men is related to increased oxidative stress and is correlated with Vx grade. CI - Copyright © 2013 Elsevier Inc. All rights reserved. FAU - Tawadrous, Gamil A AU - Tawadrous GA AD - Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Aziz, Amal A AU - Aziz AA