• PMID: 23539881
• Gene Name: IGF2
• Condition: Male infertility
• Association: In this study we have shown that IGF2 ApaI and IGF2R Gly1619Arg gene polymorphisms are not associated with male infertility.
• Mutation: IGF2 ApaI, IGF2R (Gly1619Arg)
• Population size: 211
• Population details: 211 (98 Croatian men with idiopathic infertility, 113 fertile men)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: IGF2, IGF2R
• Other associated phenotypes: Male infertility

Insulin-like growth factor 2 and insulin-like growth factor 2 receptor gene polymorphisms in idiopathic male infertility

Pereza N, Ostoji? S, Kapovi? M, Bureti?-Tomljanovi? A.

OBJECTIVE: To test the association between insulinlike growth factor 2 (IGF2) ApaI and IGF2 receptor (IGF2R) Gly1619Arg gene polymorphisms and idiopathic male infertility. STUDY DESIGN: Polymerase chain reaction and restriction fragment length polymorphism methods were performed to detect the IGF2 ApaI and IGF2R Gly1619Arg genotypes in 98 Croatian men with idiopathic infertility and 113 fertile men. RESULTS: There were no significant differences between patients and controls according to genotype (chi2(IGF2) = 3.46, p = 0.177; chi2(IGF2R) = 1.12, p= 0.571, respectively) and allele frequencies (chi2(IGF2) = 3.23, p = 0.072; chi2(IGF2R) = 0.99, p = 0.319, respectively). Odds ratios for recessive, dominant and codominant models and association testing with each genotype combination revealed no difference between infertile men and controls. CONCLUSION: In this study we have shown that IGF2 ApaI and IGF2R Gly1619Arg gene polymorphisms are not associated with male infertility. FAU - Pereza, Nina AU - Pereza N AD - Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia. nina.pereza@xnet.hr FAU - Ostojić, Sasa AU - Ostojić S FAU - Kapović, Miljenko AU - Kapović M