• PMID: 23527142
• Gene Name: CLOCK
• Condition: Male infertility
• Association: Associated
• Mutation: CLOCK (rs11932595, rs6811520, rs6850524)
• Population size: 961
• Population details: 961 (517 patients with idiopathic infertility, 444 control group of fertile men)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

Genetic variation in circadian rhythm genes CLOCK and ARNTL as risk factor for male infertility

Hod�i? A, Ristanovi? M, Zorn B, Tuli? C, Maver A, Novakovi? I, Peterlin B.

BACKGROUND: The circadian system has a major role in maintaining homeostasis and proper body functions including reproductive capacity. The aim of this study was to examine whether there is an association between genetic variability in the primary clock genes CLOCK and ARNTL and male infertility in humans. METHODOLOGY/PRINCIPAL FINDINGS: We performed a case-control study, where we searched for an association between polymorphisms of CLOCK and ARNTL genes and male infertility in 961 Slovenian and Serbian Caucasian men. The study group consisted of 517 patients with idiopathic infertility and a control group of 444 fertile men. A statistically significant difference was found in genotype distribution between the two groups in the CLOCK gene: rs11932595 (p = 6·10(-5), q = 4·10(-4), OR equaled 1.9 with 95% CI 1.4-2.7), rs6811520 (p = 2·10(-3), q = 8·10(-3), OR = 1.7 with 95% CI 1.2-2.2) and rs6850524 (p = 0.01, q = 0.02, OR = 1.4 with 95% CI 1.1-1.9). Further analyses of haplotypes were consistent with genotyping results. CONCLUSIONS/SIGNIFICANCE: We provide evidence that genetic variability in the CLOCK gene might be associated with male infertility warranting further confirmation and mechanistic investigations. FAU - Hodžić, Alenka AU - Hodžić A AD - Institute of Medical Genetics and Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Slovenia. FAU - Ristanović, Momčilo AU - Ristanović M FAU - Zorn, Branko AU - Zorn B FAU - Tulić, Cane AU - Tulić C FAU - Maver, Aleš AU - Maver A FAU - Novaković, Ivana AU - Novaković I