• PMID: 23450492
• Gene Name: GSTP1
• Condition: Azoospermia
• Association: The M1(-/-) and P1(Ile/Val or Val/Val) genotype and the M1(-/-), T1(+/+) and P1 (Ile/Val or Val/Val) genotype are associated with reduced risk of azoospermia in ethnic Chinese Han population.
• Mutation: M1 (-/-) and P1 (Ile/Val or Val/Val) genotype
• Population size: 378
• Population details: 378 (236 azoospermia patients, 142 healthy fertile male controls)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: GSTT1, GSTM1 and GSTP1
• Other associated phenotypes: Male infertility

[Association between glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1 and GSTP1) and idiopathic azoospermia]

Li C, Ding XP, Fu L, Chen L.

OBJECTIVE: To assess the association between glutathione-S-transferase gene polymorphisms GSTT1, GSTM1 and GSTP1 and onset of azoospermia. METHODS: Multi-PCR was used to detect GSTM1 and GSTT1 gene deletions. Polymorphisms of GSTP1 were determined with restriction fragment length polymorphism (RFLP) method in 236 azoospermia patients and 142 healthy fertile male controls. RESULTS: The frequency of M1 (-/-) and P1 (Ile/Val or Val/Val) genotype was 24.65% in the control group, which was significantly higher than that of the patient group (15.68%, P=0.031). Frequency of M1 (-/-), T1 (+/+) and P1 (Ile/Val or Val/Val) genotype was 12.68% in the control group, which was significantly higher than that of the patient group (5.51%, P=0.014). CONCLUSION: The M1(-/-) and P1(Ile/Val or Val/Val) genotype and the M1(-/-), T1(+/+) and P1 (Ile/Val or Val/Val) genotype are associated with reduced risk of azoospermia in ethnic Chinese Han population. FAU - Li, Chuang AU - Li C AD - School of Life Science, Sichuan University, Chengdu, Sichuan, People's Republic of China. brainding@scu.edu.cn FAU - Ding, Xian-ping AU - Ding XP FAU - Fu, Li AU - Fu L