• PMID: 23164539
• Gene Name: GSTT1
• Condition: Male factor infertility
• Association: There was evidence that the null of GSTM1 and GSTM1-GSTM1 increased the risk of male factor infertility, but the null genotype of GSTT1 was not associated with an increased infertility risk. We still need further multicenter and better controlled studies
• Sex: Male
• Infertility type: Male infertility
• Associated genes: GSTM1, GSTT1
• Other associated phenotypes: Male infertility

Null genotypes of GSTM1 and GSTT1 contribute to male factor infertility risk: a meta-analysis

Kan HP, Wu FL, Guo WB, Wang YZ, Li JP, Huang YQ, Li SG, Liu JP.

OBJECTIVE: To study the null of GSTM1, GSTT1, or GSTT1-GSTM1 and the risk of male factor infertility. DESIGN: Meta-analysis using electronic databases (Pubmed, Medline, Embase, and China National Knowledge Infrastructure) up to August 22, 2011. SETTING: The strength of the relationship between the null of GSTM1, GSTT1, and GSTT1-GSTM1 and the risk of male factor infertility was assessed by odds ratios (ORs). A total of 16 studies were identified in this meta-analysis. Among the 16 studies, 15 studies reported GSTM1null, 10 reported GSTT1, and five reported GSTM1-GSTT1. PATIENT(S): Male infertility patients and a fertile control group. INTERVENTION(S): Meta-analyses by means of random-effects models and fixed-effects models. MAIN OUTCOME MEASURE(S): Ratio of male factor infertility. RESULT(S): The studies provided overall OR estimates for GSTM1, GSTT1, and GSTM1-GSTT1, leading to a pooled OR of 1.41 (95% confidence interval [CI], 1.10-1.81), 1.15 (95% CI, 0.95-1.39), and 2.99 (95% CI, 2.14-4.18), respectively. CONCLUSION(S): There was evidence that the null of GSTM1 and GSTM1-GSTM1 increased the risk of male factor infertility, but the null genotype of GSTT1 was not associated with an increased infertility risk. We still need further multicenter and better controlled studies to confirm these findings. CI - Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. FAU - Kan, He-Ping AU - Kan HP AD - Department of Hepatobilliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China. FAU - Wu, Fang-Lei AU - Wu FL FAU - Guo, Wen-Bin AU - Guo WB FAU - Wang, Yong-Zhong AU - Wang YZ FAU - Li, Jing-Ping AU - Li JP FAU - Huang, Yu-Qi AU - Huang YQ FAU - Li, Shu-Guang AU - Li SG