• PMID: 22986331
• Gene Name: EPHX2
• Condition: Oligozoospermia, Asthenospermia
• Association: The results demonstrated that rs1042064 of EPHX2 was significantly associated with decreased risk of oligozoospermia and asthenospermia
• Mutation: rs1042064
• Population size: 1140
• Population details: 1140 (468 fertile controls, 672 idiopathic male infertile)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: EPHX1, EPHX2
• Other associated phenotypes: Oligozoospermia, Asthenospermia

Genetic variants in epoxide hydrolases modify the risk of oligozoospermia and asthenospermia in Han-Chinese population

Qin Y, Han X, Peng Y, Shen R, Guo X, Cao L, Song L, Sha J, Xia Y, Wang X.

OBJECTIVES: Epoxide hydrolases are involved in detoxifying and excreting the environmental chemicals, which are associated with decreased semen quality and male infertility. We hypothesized that polymorphisms in epoxide hydrolases may be associated with risk of oligozoospermia and asthenospermia. DESIGN AND METHODS: In this study, 468 fertile controls and 672 idiopathic male infertile patients were recruited. SNPstream and TaqMan assay were used to genotype four single nucleotide polymorphisms in EPHX1 and EPHX2. The semen analysis was performed by computer-assisted semen analysis system. RESULTS: Our results demonstrated that rs1042064 of EPHX2 was significantly associated with decreased risk of oligozoospermia (OR=0.65, 95% CI: 0.44-0.98) and asthenospermia (OR=0.66, 95% CI: 0.46-0.94). CONCLUSIONS: Our results provided evidence that genetic variants in epoxide hydrolases may modify the risk of oligozoospermia and asthenospermia in Han-Chinese population. CI - Copyright © 2012 Elsevier B.V. All rights reserved. FAU - Qin, Yufeng AU - Qin Y AD - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China. FAU - Han, Xiumei AU - Han X FAU - Peng, Yuzhu AU - Peng Y FAU - Shen, Rong AU - Shen R FAU - Guo, Xirong AU - Guo X FAU - Cao, Li AU - Cao L FAU - Song, Ling AU - Song L FAU - Sha, Jiahao AU - Sha J FAU - Xia, Yankai AU - Xia Y