• PMID: 22985582
• Gene Name: PON1
• Condition: Male infertility
• Association: The detection of seminal PON-1 activity can provide a laboratory evidence for the diagnosis of male infertility.
• Population size: 320
• Population details: 320 (270 infertile male patients, 50 health fertile males (control))
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

[Clinical value of seminal paraoxonase-1 activity evaluation in the diagnosis of male infertility]

Gong D, Li Z, Zhuang X, Zhang X, Kang M, Liao Y.

OBJECTIVE: To investigate the changes in seminal paraoxonase-1 (PON-1) activity in infertile male patients and assess the clinical value of seminal PON-1 examination in the diagnosis of male infertility. METHODS: Seminal PON-1 activity was detected by spectrophotometric method in the semen samples from 270 infertile male patients and 50 health fertile males (control), and the semen parameters were analyzed using a computer-assisted semen analysis system. RESULTS: In the male infertility group, seminal PON-1 activity was 1.22∓0.76 U/L in the patients with normal semen parameters and 0.64∓0.54 in the patients with abnormal semen parameters, both significantly lower than that of the control group (3.17∓0.89 U/L, P<0.01). In patients with asthenospermia, the declined sperm motility was associated with decreased seminal PON-1 activity, which showed significant differences between patients with mild, moderate, and severe asthenospermia. Seminal PON-1 activity was positively correlated with the percentage of sperm viability (P<0.01), but inversely with the percentage of morphologically abnormal sperm (P<0.01). According to ROC curves, the area of seminal PON-1 activity under the curve was 0.907, showing a statistical significance (P<0.01). CONCLUSION: The detection of seminal PON-1 activity can provide a laboratory evidence for the diagnosis of male infertility. FAU - Gong, Daoyuan AU - Gong D AD - Medical College of Foshan University of Science and Technology, Foshan 528000, China. gdy2814687@21cn.com FAU - Li, Ziping AU - Li Z FAU - Zhuang, Xiwei AU - Zhuang X FAU - Zhang, Xiaolin AU - Zhang X FAU - Kang, Mei AU - Kang M