• PMID: 22928696
• Gene Name: MTHFR
• Condition: Male infertility, azoospermia, severe oligozoospermia
• Association: The data suggest that the C677T MTHFR polymorphism is not a risk factor for idiopathic male subfertility in an Algerian population.
• Mutation: MTHFR 677CC, 677CT, and 677TT
• Population size: 158
• Population details: 158 (74 (46 infertile Algerian patients with NOA, 28 severe OAT), 84 fertile men as controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility, azoospermia, severe oligozoospermia

Influence of methylenetetrahydrofolate reductase C677T gene polymorphisms in Algerian infertile men with azoospermia or severe oligozoospermia

Chellat D, Rezgoune ML, Hamane D, Semmame O, Benlatrèche C, Abadi N, Satta D.

AIMS: The C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene has been suggested to represent a risk factor for male infertility. To confirm this association, the distribution of the single-nucleotide polymorphism C677T was investigated in idiopathic infertile Algerian patients with nonobstructive azoospermia (NOA) or severe oligoasthenoteratozoospermia (OAT). A case-control study was carried out, including 74 idiopathic infertile Algerian patients with NOA (n=46) or severe OAT (n=28) and 84 fertile men as controls. Polymorphism C677T was studied by polymerase chain reaction-restriction fragment length polymorphism, and the results were statistically analyzed. RESULTS: The frequency of genotypes MTHFR 677CC, 677CT, and 677TT in idiopathic infertile men with NOA was 43.48%, 41.30%, and 15.22%; 39.29%, 50%, and 10.71% regarding the severe oligozoospermic men; and 42.86%, 45.24%, and 11.90% in the control group. CONCLUSIONS: The data suggest that the C677T MTHFR polymorphism is not a risk factor for idiopathic male subfertility in an Algerian population. FAU - Chellat, Djalila AU - Chellat D AD - Faculty of Natural and Life Sciences, Department of Animal Biology, Laboratory of Biology and Molecular Genetics, University Mentouri Constantine, Constantine, Algeria. rezgounedj@yahoo.fr FAU - Rezgoune, Mohamed Larbi AU - Rezgoune ML FAU - Hamane, Douadi AU - Hamane D FAU - Semmame, Ouarda AU - Semmame O FAU - Benlatrèche, Cherifa AU - Benlatrèche C FAU - Abadi, Noureddine AU - Abadi N