• PMID: 22903474
• Gene Name: GSTT1
• Condition: Male factor infertility
• Association: These results demonstrated that amongst populations studied to date, GSTM1 and GSTT1 null genotypes are associated with strong and modest increase in the risk of male infertility, respectively. On the contrary, GSTP1 Ile/Val genotype has protective effect
• Mutation: GSTP1 Ile/Val genotype
• Population size: 2377
• Population details: 2377 (1323 cases, 1054 controls)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: GSTM1, GSTT1, and GSTP1
• Other associated phenotypes: Male infertility

Glutathione S-transferase polymorphisms (GSTM1, GSTT1, GSTP1) and male factor infertility risk: a pooled analysis of studies

Safarinejad MR, Dadkhah F, Ali Asgari M, Hosseini SY, Kolahi AA, Iran-Pour E.

PURPOSE: To determine the role of glutathione S-transferases (GSTs; GSTM1, GSTT1, and GSTP1) gene polymorphisms in susceptibility to male factor infertility. MATERIALS AND METHODS: We report a pooled analysis of 11 studies on the association of GSTM1, GSTT1, and GSTP1 polymorphisms and male factor infertility, including 1323 cases and 1054 controls. RESULTS: An overall significant association was determined between the GSTM1 null genotype [odds ratio (OR), 2.74; 95% confidence interval (CI), 1.72 to 3.84; P = .003], GSTT1 null genotype (OR, 1.54; 95% CI, 1.43 to 3.47; P = .02), and male factor infertility. The GSTP1 Ile/Val genotype had overall protective effect against development of infertility (OR, 0.48; 95% CI, 0.27 to 0.77), while there was significant heterogeneity between studies. In sensitivity analysis, two studies were excluded; the association and direction between GSTM1 and GSTT1 null genotypes and GSTP1 Ile/Val genotype and male infertility remained unchanged. There was no significant interaction between smoking status and studied genotypes on male infertility risk (P = .26). CONCLUSION: These results demonstrated that amongst populations studied to date, GSTM1 and GSTT1 null genotypes are associated with strong and modest increase in the risk of male infertility, respectively. On the contrary, GSTP1 Ile/Val genotype has protective effect. FAU - Safarinejad, Mohammad Reza AU - Safarinejad MR AD - Clinical Center for Urological Disease Diagnosis and Private Clinic Specialized in Urological and Andrological Genetics, Tehran, Iran. info@safarinejad.com FAU - Dadkhah, Farid AU - Dadkhah F FAU - Ali Asgari, Majid AU - Ali Asgari M FAU - Hosseini, Seyed Yousef AU - Hosseini SY FAU - Kolahi, Ali Asgar AU - Kolahi AA