• PMID: 22581801
• Gene Name: TEX15
• Condition: Spermatogenic failure
• Association: Associated
• Mutation: Tex15 (rs323346, rs323347)
• Population size: 686
• Population details: 686 (309 infertile men with nonobstructive azoospermia (NOA, n = 199) or severe oligozoospermia (SO, n = 110) and 377 fertile controls)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: TEX15
• Other associated phenotypes: Spermatogenic failure

Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population

Ruan J, He XJ, Du WD, Chen G, Zhou Y, Xu S, Zuo XB, Fang LB, Cao YX, Zhang XJ.

This study aimed to analyze the distribution of single-nucleotide polymorphisms (SNPs) of testis-expressed 15 (TEX15) gene in the Chinese Han infertile men and fertile men. This case-control study comprised 309 infertile men with nonobstructive azoospermia (NOA, n = 199) or severe oligozoospermia (SO, n = 110) and 377 fertile controls. Six SNPs were genotyped by Sequenom iplex technology. The results showed that the variants rs323346 and rs323347 contributed to the increasing risk of SO (P = .041, odds ratio [OR] = 1.635, 95% confidence interval [CI] = 1.018-2.628 and P = .046, OR = 1.616, 95% CI = 1.006-2.597). The haplotype AT of the SNPs rs323347 and rs323346 could reduce risk in the patients with SO (P = .040, OR = 0.616, and 95% CI = 0.383-0.990). The haplotype GC of the variants rs323347 and rs323346 conferred a significantly increased risk of SO (P = .040, OR = 1.624, 95% CI = 1.010-2.610). Thus, the polymorphisms rs323346 and rs323347 of the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population. FAU - Ruan, Jian AU - Ruan J AD - Key Lab of Genome Research of Anhui Province, Anhui Medical University, Hefei, China. FAU - He, Xiao-Jin AU - He XJ FAU - Du, Wei-Dong AU - Du WD FAU - Chen, Gang AU - Chen G FAU - Zhou, Yuan AU - Zhou Y FAU - Xu, Song AU - Xu S FAU - Zuo, Xian-Bo AU - Zuo XB FAU - Fang, Li-Bin AU - Fang LB FAU - Cao, Yun-Xia AU - Cao YX