• PMID: 22425118
• Gene Name: ACE
• Condition: Asthenozoospermia, Asthenoteratozoospermia and Oligoasthenoteratozoospermia
• Association: ACE gene deletion polymorphism is associated with abnormal seminal variables, such that carriers of the ACEdeletion/deletion genotype have higher seminal oxidative stress.
• Population size: 405
• Population details: 405
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

ACE gene insertion/deletion polymorphism seminal associations in infertile men

Zalata AA, Morsy HK, Badawy Ael-N, Elhanbly S, Mostafa T.

PURPOSE: We assessed seminal associations of the ACE gene insertion/deletion polymorphism in infertile men. MATERIALS AND METHODS: A total of 405 men were investigated, divided into healthy fertile men, and those with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia, respectively. They underwent semen analysis, and assessment of sperm acrosin activity, hypo-osmotic swelling, seminal 8-iso-prostaglandin-F(2α), total antioxidant capacity, α-glucosidase and ACE gene polymorphisms. RESULT: The ACE insertion/insertion genotype was noted in 182 men, including 76.5% of healthy fertile men, and 47.4%, 39.8% and 17.6% of those with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia, respectively. The ACE insertion/deletion genotype was noted in 133 men, including 13.7% of healthy fertile men, and 42.3%, 27.5% and 47.2% of those with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia, respectively. The ACE deletion/deletion genotype was identified in 90 men, including 9.8% of healthy fertile men, 10.3%, 32.70% and 35.2% of those with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia, respectively. Men with the ACE deletion/deletion and insertion/deletion genotypes showed a significant decrease in sperm count, motility, linear velocity and normal forms, acrosin activity index, hypo-osmotic swelling test and seminal α-glucosidase, and significantly increased seminal 8-iso-prostaglandin-F(2α) than those with the ACE insertion/insertion genotype. CONCLUSIONS: ACE gene deletion polymorphism is associated with abnormal seminal variables, such that carriers of the ACE deletion/deletion genotype have higher seminal oxidative stress. CI - Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. FAU - Zalata, Adel A AU - Zalata AA AD - Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt. FAU - Morsy, Heba K AU - Morsy HK FAU - Badawy, Abd El-Naser AU - Badawy Ael-N FAU - Elhanbly, Samir AU - Elhanbly S