• PMID: 22414334
• Gene Name: FSHR
• Condition: Male infertility, azoospermia, oligoasthenoteratozoospermia (OAT)
• Association: This meta-analysis supports that FSHR G-29A, Thr(307)Ala and Asn(680)Ser polymorphisms may not be capable of causing male infertility susceptibility.
• Mutation: FSHR G-29A (rs1394205), 919A>G (Thr(307)Ala, rs6165), 2039A>G (Asn(680)Ser, rs6166)
• Population size: 3392
• Population details: 3392 (1644 male infertility cases, 1748 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility, azoospermia, oligoasthenoteratozoospermia (OAT)

Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility: a meta-analysis

Wu W, Cai H, Sun H, Lu J, Zhao D, Qin Y, Han X, Niu X, Lu C, Xia Y, Wang S, De Moor B, Marchal K, Wang X.

Studies of the relationship between male infertility and polymorphisms in the regions of FSHR G-29A (rs1394205), 919A>G (Thr(307)Ala, rs6165) and 2039A>G (Asn(680)Ser, rs6166) have reported inconsistent results. To assess the association between them, a meta-analysis was conducted. PubMed and CBMdisc literature search were conducted to identify all eligible studies investigating such a relationship. The pooled ORs were performed for co-dominant model, dominant model and recessive model in FSHR G-29A, Thr(307)Ala and Asn(680)Ser respectively to assess the strength of association. A total of 1644 male infertility cases and 1748 controls were collected from seven case-control studies. In the overall analysis, no significant association between the three polymorphisms and risk of male infertility was observed. Stratified analysis showed that there were no significantly increased risks of azoospermia and oligoasthenoteratozoospermia (OAT) in any of the genetic models. This meta-analysis supports that FSHR G-29A, Thr(307)Ala and Asn(680)Ser polymorphisms may not be capable of causing male infertility susceptibility. CI - Copyright © 2012 Elsevier B.V. All rights reserved. FAU - Wu, Wei AU - Wu W AD - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China. FAU - Cai, Hongquan AU - Cai H FAU - Sun, Hong AU - Sun H FAU - Lu, Jing AU - Lu J FAU - Zhao, Dan AU - Zhao D FAU - Qin, Yufeng AU - Qin Y FAU - Han, Xiumei AU - Han X FAU - Niu, Xiaobing AU - Niu X FAU - Lu, Chuncheng AU - Lu C FAU - Xia, Yankai AU - Xia Y FAU - Wang, Shoulin AU - Wang S FAU - De Moor, Bart AU - De Moor B FAU - Marchal, Kathleen AU - Marchal K