• PMID: 22182811
• Gene Name: AZGP1
• Condition: Oligospermia
• Association: Associated
• Age: 20 to 40 years
• Sex: Male
• Infertility type: Male infertility
• Associated genes: Lactoferrin, Prostatic acid phosphatase, Human Zinc-Alpha-2-Glycoprotein, Prostate specific antigen, Progestagen-associated endometrial protein, Kinesin light chain 4, Kinesin light chain 4, Prolactin inducible protein, Izumo sperm-egg fusion protein 1
• Other associated phenotypes: Azoospermia, Oligospermia

Isolation and identification of Concanavalin A binding glycoproteins from human seminal plasma: a step towards identification of male infertility marker proteins

Tomar AK, Sooch BS, Raj I, Singh S, Singh TP, Yadav S.

Human seminal plasma contains a large array of proteins of clinical importance which are essentially needed to maintain the reproductive physiology of spermatozoa and for successful fertilization. Thus, isolation and identification of seminal plasma proteins is of paramount significance for their biophysical characterization and functional analysis in reproductive physiological processes. In this study, we have isolated Concanavalin-A binding glycoproteins from human seminal plasma and subsequently identified them by MALDI-TOF/MS analysis. The major proteins, as identified in this study, are Aminopeptidase N, lactoferrin, prostatic acid phosphatase, zinc-alpha-2-glycoprotein, prostate specific antigen, progestagen-associated endometrial protein, Izumo sperm-egg fusion protein and prolactin inducible protein. This paper also reports preliminary studies to identify altered expression of these proteins in oligospermia and azoospermia in comparison to normospermia. In oligospermia, five proteins were found to be downregulated while in azoospermia, four proteins were downregulated and two proteins were upregulated. Thus, this study is of immense biomedical interest towards identification of potential male infertility marker proteins in seminal plasma. FAU - Tomar, Anil Kumar AU - Tomar AK AD - Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India. FAU - Sooch, Balwinder Singh AU - Sooch BS FAU - Raj, Isha AU - Raj I FAU - Singh, Sarman AU - Singh S FAU - Singh, Tej P AU - Singh TP