• PMID: 21919946
• Gene Name: ADA1
• Condition: Male infertility
• Association: Associated
• Population size: 125
• Population details: 125 (55 fertile men, 70 infertile men)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: ADAT, ADA2 and ADA1
• Other associated phenotypes: Male infertility

Adenosine deaminase activity in fertile and infertile men

Rostampour F, Biglari M, Vaisi-Raygani A, Salimi S, Tavilani H.

Adenosine deaminase (ADA; E.C.3.5.4.4) catalyses the deamination of adenosine to inosine. In the human reproductive system, the importance of enzymes that affect metabolism of adenosine, particularly adenosine deaminase, has been noticed. The purpose of this study was to determine the plasma activities of total adenosine deaminase (ADAT), and its isoenzymes, ADA1 and ADA2, in fertile and infertile men. Plasma activities of ADA and its isoenzymes were measured in 55 fertile men and 70 infertile men. There was a significant difference in the ADA1 and ADA2 activities between fertile and infertile individuals (P < 0.01). The activity of ADAT, ADA2 and ADA1 in infertile men was higher than that in fertile individuals. This alteration in ADA activity can lead to reduced adenosine levels, which may be involved in disturbing the fertility process. CI - © 2011 Blackwell Verlag GmbH. FAU - Rostampour, F AU - Rostampour F AD - Department of Biochemistry, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran. FAU - Biglari, M AU - Biglari M FAU - Vaisi-Raygani, A AU - Vaisi-Raygani A FAU - Salimi, S AU - Salimi S