• PMID: 21870185
• Gene Name: HLA-B
• Condition: Idiopathic male infertility
• Association: HLA-B gene was unlikely a major risk factor of idiopathic male infertility in this sample population. As different populations have different HLA polymorphisms, investigation of the relationship of other HLA genes and idiopathic male infertility with larg
• Population size: 261
• Population details: 261 (109 patients with idiopathic male infertility, 152 healthy controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Idiopathic male infertility

Association study of HLA-B alleles with idiopathic male infertility in Han population of China

Zhou DX, Zhang J, Wang HX, Wang XF, Tian Z, Zhao WB, Han SP, Zhang J, Huo YW, Tian H.

PURPOSE: To investigate the distributions of HLA-B alleles and estimate their associations with idiopathic male infertility in Chinese Han population. METHODS: Polymerase chain reaction-sequence-based typing (PCR-SBT) method was used for DNA typing at HLA-B locus in 109 patients with idiopathic male infertility and 152 healthy controls in male Han population of Shaanxi Province, situated in northwestern China. RESULTS: In total, we detected 45 HLA-B alleles in idiopathic infertile patients, 48 HLA-B alleles in control subjects. However, no significant differences of these allelic frequencies were found between the infertile patients and the controls. CONCLUSION: HLA-B gene was unlikely a major risk factor of idiopathic male infertility in this sample population. As different populations have different HLA polymorphisms, investigation of the relationship of other HLA genes and idiopathic male infertility with larger sample size, is warranted in the future. FAU - Zhou, Dang-Xia AU - Zhou DX AD - Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 710061, China. dangxia75@163.com FAU - Zhang, Jing AU - Zhang J FAU - Wang, Hai-Xu AU - Wang HX FAU - Wang, Xiao-Fang AU - Wang XF FAU - Tian, Zhao AU - Tian Z FAU - Zhao, Wen-Bao AU - Zhao WB FAU - Han, Shui-Ping AU - Han SP FAU - Zhang, Jian AU - Zhang J FAU - Huo, Yong-Wei AU - Huo YW