• PMID: 21868008
• Gene Name: CASP9
• Condition: Oligoasthenoteratozoospermia, varicocoele, male infertility
• Association: Sperm caspase-9 is exaggerated in infertile OAT cases with varicocele compared with infertile OAT cases without varicocele or healthy fertile men. Sperm caspase-9 demonstrated significant negative correlation with semen variables.
• Population size: 80
• Population details: 80 (20 healthy fertile men, 25 men with oligoasthenoteratozoospermia, 35 men with oligoasthenoteratozoospermia with left-side varicocele )
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Oligoasthenoteratozoospermia, varicocoele, male infertility

Sperm caspase-9 in oligoasthenoteratozoospermic men with and without varicocele

Zalata A, El-Mogy M, Abdel-Khabir A, El-Bayoumy Y, El-Baz M, Mostafa T.

OBJECTIVE: To assess sperm caspase-9 activity in infertile oligoasthenoteratozoospermic (OAT) men with and without varicocele. DESIGN: Prospective. SETTING: Academic setting. PATIENT(S): Eighty men: healthy fertile control subjects (n = 20), OAT (n = 25), and OAT associated with left-side varicocele (n = 35). INTERVENTION(S): History taking, clinical examination, semen analysis,assessment of seminal caspase-9. MAIN OUTCOME MEASURE(S): Semen analysis, sperm caspase-9. RESULT(S): Sperm caspase-9 was significantly increased in infertile OAT men associated with varicocele compared with OAT men without varicocele and healthy fertile control subjects. Sperm casapse-9 activity demonstrated significant negative correlation with sperm count, sperm motility, sperm velocity, sperm linear velocity, sperm linearity index, and sperm normal morphology. CONCLUSION(S): Sperm caspase-9 is exaggerated in infertile OAT cases with varicocele compared with infertile OAT cases without varicocele or healthy fertile men. Sperm caspase-9 demonstrated significant negative correlation with semen variables. CI - Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. FAU - Zalata, Adel AU - Zalata A AD - Medical Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - El-Mogy, Mohamed AU - El-Mogy M FAU - Abdel-Khabir, Ahmed AU - Abdel-Khabir A FAU - El-Bayoumy, Youssef AU - El-Bayoumy Y FAU - El-Baz, Mohamed AU - El-Baz M