• PMID: 21848911
• Gene Name: FN1
• Condition: Asthenozoospermia, asthenoteratozoospermia, oligoasthenoteratozoospermia, controls
• Association: Associated
• Population size: 110
• Population details: 110 (90 infertile males (27 asthenozoospermia, 30 asthenoteratozoospermia, 33 oligoasthenoteratozoospermia), 20 healthy fertile controls)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: fibronectin
• Other associated phenotypes: Asthenozoospermia, asthenoteratozoospermia, oligoasthenoteratozoospermia, controls

Seminal fibronectin in fertile and infertile males

Attia AM, Hassan A, Zalata A, Hagag M, Yousef KE, Mostafa T.

This study aimed to assess seminal plasma fibronectin in fertile and infertile males. Ninety infertile males were investigated; asthenozoospermia (n = 27), asthenoteratozoospermia (n = 30), oligoasthenoteratozoospermia (n = 33) compared with 20 healthy fertile controls. They were subjected to semen analysis, seminal plasma fibronectin estimation by radial immune diffusion, serum testosterone (T) and follicle stimulating hormone (FSH) estimation by ELISA. There was significant increase of seminal plasma fibronectin among different infertile groups compared with the controls. Significant negative correlation was elicited between seminal fibronectin and sperm count, sperm motility grades A, B, A + B, sperm velocity, linear velocity, linearity index, sperm normal forms and serum T. Seminal fibronectin showed significant positive correlation with grade D sperm motility and serum FSH. ROC curve analysis discriminating controls and other infertile groups demonstrated criteria value of < 674 mg l(-1) (sensitivity 100% and specificity 96.4%). It is concluded that increased seminal fibronectin is associated with decreased sperm count and sperm motility. CI - © 2011 Blackwell Verlag GmbH. FAU - Attia, A M AU - Attia AM AD - Department of Dermatology and Andrology, Faculty of Medicine, Minofiya University, Egypt. FAU - Hassan, A AU - Hassan A FAU - Zalata, A AU - Zalata A FAU - Hagag, M AU - Hagag M FAU - Yousef, K E AU - Yousef KE