• PMID: 21740905
• Gene Name: CCNT2
• Condition: Role in spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Role In spermatogenesis

Cyclin T2: a novel miR-15a target gene involved in early spermatogenesis

Teng Y, Wang Y, Fu J, Cheng X, Miao S, Wang L.

MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression that play important roles in various biological processes. Spermatogenesis is a highly regulated process in which diploid spermatogonia eventually differentiate into haploid spermatozoa. In this study, we identified four differentially expressed miRNAs between two premeiotic male germ cells, made predictions about their putative targets, and confirmed cyclin T2 (Ccnt2) as a direct target of miR-15a. We also report that miR-15a inhibited muscle differentiation at least in part by targeting Ccnt2, which represents a novel interaction. Subsequently, miR-15a and Ccnt2 were profiled in developing mice testes to observe their inverse correlations in the postnatal 3-week period to understand their roles in spermatogenesis. CI - Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. FAU - Teng, Yu AU - Teng Y AD - State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, China. FAU - Wang, Yong AU - Wang Y FAU - Fu, Jun AU - Fu J FAU - Cheng, Xiaowen AU - Cheng X FAU - Miao, Shiying AU - Miao S