• PMID: 21735657
• Gene Name: DAZ3
• Condition: Male infertility
• Association: Thirteen studies showed that oligozoospermia patients had a significantly higher frequency ofgr/gr deletion than controls. Eight studies showed a significant association between the gr/gr deletion subtype without DAZ1/DAZ2 gene copies and spermatogenic im
• Mutation: gr/gr deletion
• Population size: 9626
• Population details: 9626 (5246 cases of idiopathic infertility, 4380 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

[Association of gr/gr deletion in the AZFc region of Y chromosome with male infertility: a meta-analysis]

Li Y, Pan KJ, Wang L, Ren J.

OBJECTIVE: To evaluate the association of gr/gr deletion in the AZFc region of Y chromosome with idiopathic male infertility using Meta-analysis. METHODS: All relevant case-control studies addressing the relationship between gr/gr deletion and idiopathic male infertility were identified from PubMed, VIP and CNKI (from January 2003 to August 2010). Statistical analyses were performed with the RevMan4. 2 software. RESULTS: Twenty eligible articles were selected in this study, including 5 246 cases of idiopathic infertility and 4 380 controls. The integrated data from the 20 studies revealed a significantly higher frequency of gr/gr deletion in the patients than in the controls, with an odds ratio (OR) of 1.63 (95% CI: 1.23 -2.44) (P = 0.002). However, when the Meta-analysis was limited to 16 studies with stricter case and control selection criteria, the overall OR increased to 1.84 (95% CI: 1.47 - 2.29) (P < 0.000 01). Thirteen studies showed that oligozoospermia patients had a significantly higher frequency of gr/gr deletion than controls (OR = 2.12, 95% CI: 1.61 - 2.80) (P < 0.000 01). Eight studies showed a significant association between the gr/gr deletion subtype without DAZ1/DAZ2 gene copies and spermatogenic impairment (OR = 1.83, 95% CI: 1.31 - 2.55) (P = 0.000 4), but no statistically significant differences were found in the frequency distribution of the gr/gr deletion subtype missing DAZ3/DAZ4 gene copies between the patients and controls (OR = 1.43, 95% CI: 0.97 -2.11) (P = 0.07). CONCLUSION: The present data suggest that gr/gr deletion may be one of the risk factors of male infertility. FAU - Li, Ya AU - Li Y AD - Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Chengdu Medical College, Chengdu, Sichuan 610083, China. liyalhj@tom.com FAU - Pan, Ke-Jian AU - Pan KJ FAU - Wang, Lan AU - Wang L