• PMID: 21550039
• Gene Name: HER2
• Condition: Spermatogenic defects
• Association: Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells, suggesting that activated HER2 participates in mitosis and meiot
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Spermatogenic defects

Expression of activated HER2 in human testes

Shin I, Kim HJ, Nah WH, Park HJ, Gye MC, Park HY.

The HER2 messenger RNA (mRNA) was the most abundant among the erb type-1 tyrosine kinase receptors mRNA in human testis and was statistically significantly decreased in impaired spermatogenesis. Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells, suggesting that activated HER2 participates in mitosis and meiotic entry of germ cells, spermiogenesis, and steroidogenesis via mediating the epidermal growth factor-growth factor signaling. CI - Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. FAU - Shin, Inchoel AU - Shin I AD - Department of Life Science and Institute for Natural Sciences, Hanyang University, Seoul, South Korea. FAU - Kim, Hyun Joo AU - Kim HJ FAU - Nah, Won Heum AU - Nah WH FAU - Park, Hyun Jun AU - Park HJ FAU - Gye, Myung Chan AU - Gye MC