• PMID: 21536282
• Gene Name: SEMG2
• Condition: Male infertility
• Association: Four unique proteins, semenogelin II precursor, prolactin-induced protein, clusterin isoform 1, and prostate-specific antigen isoform 1 preproprotein, were predominantly present in the semen of healthy men; however, semenogelin II precursor and clusterin
• Sex: Male
• Infertility type: Male infertility
• Associated genes: Semenogelin II precursor, clusterin isoform 1
• Other associated phenotypes: Male infertility

Evaluation of sperm proteins in infertile men: a proteomic approach

Thacker S, Yadav SP, Sharma RK, Kashou A, Willard B, Zhang D, Agarwal A.

In this study, the sperm protein profile was compared between fertile and infertile men using 2-dimensional gel electrophoresis, liquid chromatography mass spectrometer analysis, and matrix-assisted laser desorption ionization-time-of-flight-mass spectrometry. Four unique proteins, semenogelin II precursor, prolactin-induced protein, clusterin isoform 1, and prostate-specific antigen isoform 1 preproprotein, were predominantly present in the semen of healthy men; however, semenogelin II precursor and clusterin isoform 1 were not seen in the semen of infertile men, suggesting unique differences in the spermatozoa protein profiles of fertile and infertile men. CI - Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. FAU - Thacker, Stetson AU - Thacker S AD - Molecular Biotechnology Core Laboratory, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. FAU - Yadav, Satya P AU - Yadav SP FAU - Sharma, Rakesh K AU - Sharma RK FAU - Kashou, Anthony AU - Kashou A FAU - Willard, Belinda AU - Willard B FAU - Zhang, Dongmei AU - Zhang D