• PMID: 21350240
• Gene Name: TNFR2
• Condition: Infertility
• Association: No significant associations were found between TNF? -857C?T and TNFR2 676T?G polymorphisms and semen quality. The TNFR1 36A allele is associated with increased sperm concentration and motility in our series, supporting the significance of TNFR1 gene in se
• Mutation: TNF? -857C?T, TNFR1 36A?G, and TNFR2 676T?G polymorphisms
• Population size: 290
• Population details: 290 (170 normozoospermic, 120 oligospermic )
• Sex: Male
• Infertility type: Male infertility
• Associated genes: TNF?, TNFR2
• Other associated phenotypes: Male infertility

Association of TNF?, TNFR1, and TNFR2 polymorphisms with sperm concentration and motility

Lazaros LA, Xita NV, Chatzikyriakidou AL, Kaponis AI, Grigoriadis NG, Hatzi EG, Grigoriadis IG, Sofikitis NV, Zikopoulos KA, Georgiou IA.

Tumor necrosis factor α (TNFα) is a multifunctional cytokine that regulates various cellular processes related to spermatogenesis. Two types of cell receptors, TNFR1 and TNFR2, mediate TNFα activity. In the present study, we sought to explore the association of TNFα -857C→T, TNFR1 36A→G, and TNFR2 676T→G polymorphisms with sperm concentration and motility. Two hundred ninety men were examined during infertility investigation; of those, 170 men were normozoospermic and 120 were oligospermic. Polymerase chain reaction analysis revealed significant differences in genotype distribution of the TNFR1 36A→G polymorphism between normozoospermic and oligospermic men. Men with oligozoospermia presented TNFR1 36A/A genotypes less frequently than normozoospermic men (P < .001). The presence of the TNFR1 36G allele was significantly increased in oligospermic men (P < .001). Furthermore, the presence of the TNFR1 36G allele was associated with lower sperm concentration in normozoospermic men (P < .03) and in the total study population (P < .001), and with lower sperm motility in normozoospermic men (P < .007) and in the total study population (P < .001). No significant associations were found between TNFα -857C→T and TNFR2 676T→G polymorphisms and semen quality. The TNFR1 36A allele is associated with increased sperm concentration and motility in our series, supporting the significance of TNFR1 gene in semen quality. FAU - Lazaros, Leandros A AU - Lazaros LA AD - Genetics and IVF Unit, Laboratory of Medical Genetics and Human Reproduction, Department of Obstetrics and Gynecology, Medical School, University of Ioannina, Ioannina, Greece. FAU - Xita, Nectaria V AU - Xita NV FAU - Chatzikyriakidou, Anthoula L AU - Chatzikyriakidou AL FAU - Kaponis, Apostolos I AU - Kaponis AI FAU - Grigoriadis, Nicolaos G AU - Grigoriadis NG FAU - Hatzi, Elissavet G AU - Hatzi EG FAU - Grigoriadis, Ioannis G AU - Grigoriadis IG FAU - Sofikitis, Nikolaos V AU - Sofikitis NV FAU - Zikopoulos, Konstantinos A AU - Zikopoulos KA