• PMID: 21310149
• Gene Name: RANBP1
• Condition: Male infertility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

Mice lacking Ran binding protein 1 are viable and show male infertility

Nagai M, Moriyama T, Mehmood R, Tokuhiro K, Ikawa M, Okabe M, Tanaka H, Yoneda Y.

The small GTPase Ran plays important roles in multiple aspects of cellular function. Maximal RanGAP activity is achieved with the aid of RanBP1 and/or presumably of RanBP2. Here, we show that RanBP1-knockout mice are unexpectedly viable, and exhibit male infertility due to a spermatogenesis arrest, presumably caused by down-regulation of RanBP2 during spermatogenesis. Indeed, siRNA-mediated depletion of RanBP2 caused severe cell death only in RanBP1-deficient MEFs, indicating that simultaneous depletion of RanBP1 and RanBP2 severely affects normal cell viability. Collectively, we conclude that the dramatic decrease in "RanBP" activity impairs germ cell viability and affects spermatogenesis decisively in RanBP1-knockout mice. CI - Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. FAU - Nagai, Masahiro AU - Nagai M AD - Biomolecular Dynamics Laboratory, Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan. FAU - Moriyama, Tetsuji AU - Moriyama T FAU - Mehmood, Rashid AU - Mehmood R FAU - Tokuhiro, Keizo AU - Tokuhiro K FAU - Ikawa, Masahito AU - Ikawa M FAU - Okabe, Masaru AU - Okabe M FAU - Tanaka, Hiromitsu AU - Tanaka H