• PMID: 21244563
• Gene Name: TNF
• Condition: Male infertility
• Association: IL-23 contents of semen are different in the normal and abnormal group and have positive correlations between IL-6, IL-8, and TNF-?, respectively.
• Population size: 57
• Population details: 59 (33 normal group, 24abnormal group, )
• Sex: Male
• Infertility type: Male infertility
• Associated genes: IL-23, IL-6, TNF-?
• Other associated phenotypes: Male infertility

Study on the relationship between different cytokines in the semen of infertility patients

Qian L, Sun G, Zhou B, Wang G, Song J, He H.

PROBLEM: The relationship between different cytokines in the semen of infertility patients was investigated. METHOD OF STUDY: Fifty-seven semen samples were collected from infertility and normal group at Lianyungang Maternal and Child Hospital. Routine analysis including determination of the levels of IL-23, IL-6, and TNF-α was carried out. RESULTS: Density, percentage of sperm moving forward, activity, survival rate, and proportion of normal morphology of sperm of normal group were significantly higher than those of infertility group (P<0.001). Amount and pH of the semen from the two groups showed no difference. However, there is a significant difference in IL-23 contents of semen in the normal (5.87 pg/mL) and abnormal (11.14 pg/mL) group (P<0.001). The correlation coefficients (R) of the contents of IL-23 to IL-6, IL-8, and TNF-α were 0.8706 (R(2)=0.758, P<0.001), 0.9725 (R(2)=0.9458, P<0.001), and 0.9499 (R(2)=0.9024, P<0.001), respectively. CONCLUSION: IL-23 contents of semen are different in the normal and abnormal group and have positive correlations between IL-6, IL-8, and TNF-α, respectively. CI - © 2011 John Wiley & Sons A/S. FAU - Qian, Li AU - Qian L AD - Central Laboratory, Maternal and Child Health Hospital of Liayungang City, 10 Camgwu Road, Lianyungang, China. qianli008@yahoo.com FAU - Sun, Gang AU - Sun G FAU - Zhou, Baocheng AU - Zhou B FAU - Wang, Gang AU - Wang G FAU - Song, Jicheng AU - Song J