• PMID: 21184802
• Gene Name: RANBP17
• Condition: May have a role in sex chromosome inactivation during the meiotic phase of spermatogenesis, and in the intramanchette transport during spermiogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: May have a role in sex chromosome inactivation during the meiotic phase of spermatogenesis, and in the intramanchette transport during spermiogenesis

RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids

Bao J, Wu Q, Song R, Jie Z, Zheng H, Xu C, Yan W.

We identified Ran-binding protein 17 (RANBP17) as one of the interacting partners of sperm maturation 1 (SPEM1) using yeast 2-hybrid screening and immunoprecipitation assays. Expression profiling analyses suggested that RANBP17 was preferentially expressed in the testis. Immunofluorescent confocal microscopy revealed a dynamic localization pattern of RANBP17 during spermatogenesis. In primary spermatocytes RANBP17 was mainly localized to the XY body. In the subsequent spermiogenesis, RANBP17 was first observed in the nuclei of round spermatids (steps 1-7) and then confined to the manchette of elongating spermatids (steps 8-14) together with its interacting partner SPEM1. In the Spem1-null testes, levels of RANBP17 were significantly elevated. As a member of a large protein family involved in the nucleocytoplasmic transport, RANBP17 may have a role in sex chromosome inactivation during the meiotic phase of spermatogenesis, and also in the intramanchette transport during spermiogenesis. Interactions between RANBP17 and SPEM1, for the first time, point to a potential function of SPEM1 in the RANBP17-mediated nucleocytoplasmic transport. CI - Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. FAU - Bao, Jianqiang AU - Bao J AD - Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA. FAU - Wu, Qiuxia AU - Wu Q FAU - Song, Rui AU - Song R FAU - Jie, Zhang AU - Jie Z FAU - Zheng, Huili AU - Zheng H FAU - Xu, Chen AU - Xu C