• PMID: 21104644
• Gene Name: FSH
• Condition: Impaired spermatogenesis
• Association: Associated
• Population size: 84
• Population details: 84 (46 men with oligozoospermia, 38 normozoospermic, fertile controls)
• Sex: Male
• Infertility type: Male Infertility
• Associated genes: inhibin B, FSH
• Other associated phenotypes: Sertoli cell function in impaired spermatogenesis

Inhibin B and FSH as markers of Sertoli cell function in impaired spermatogenesis

M?dra? M, Trzmiel-Bira A, Jó?ków P, Terpi?owski L, Zagocka E, Sici?ska-Werner T.

INTRODUCTION: The relationships between inhibin B, FSH and sperm count have never been fully elucidated. Our aim was to search for associations between serum concentrations of inhibin B/FSH and the impairment of spermatogenesis. MATERIAL AND METHODS: In an observational study, we compared sperm count, serum levels of inhibin B and FSH in men with oligozoospermia (n = 46) and in normozoospermic, fertile controls (n = 38). RESULTS: Concentration of FSH was 10.27 ± 11.24 IU/L in the oligozoospermic and 3.84 ± 2.76 IU/L in the normospermic group (p 〈 0.01). Although the concentration of inhibin B was higher in the oligozoospermic group (424 ± 443 v. 297 ± 219 pg/mL), the difference was statistically insignificant. CONCLUSIONS: Our results suggest that there is a tendency toward increased serum inhibin B levels in subjects with altered sperm count and increased serum FSH. FAU - Mędraś, Marek AU - Mędraś M AD - Department of Endocrinology, Wroclaw Medical University, Wroclaw, Poland. FAU - Trzmiel-Bira, Anna AU - Trzmiel-Bira A FAU - Jóźków, Paweł AU - Jóźków P FAU - Terpiłowski, Lukasz AU - Terpiłowski L FAU - Zagocka, Ewa AU - Zagocka E