• PMID: 20850723
• Gene Name: CLDN11
• Condition: Sertoli cell only (SCO) testes, hypospermatogenesis, spermatocytic and maturation arrest
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: claudin-11
• Other associated phenotypes: Sertoli cell only (SCO) testes, hypospermatogenesis, spermatocytic and maturation arrest

Claudin-11 expression increased in spermatogenic defect in human testes

Nah WH, Lee JE, Park HJ, Park NC, Gye MC.

Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes. Increased claudin-11 immunoreactivity was observed at the inter-Sertoli tight junctions in maturation arrest and in the cytoplasm of Sertoli cells in SCO. The late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the BTB in the human testis. CI - Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. FAU - Nah, Won Heum AU - Nah WH AD - Department of Life Science, College of Natural Sciences, Hanyang University, Seoul, South Korea. FAU - Lee, Jae Eun AU - Lee JE FAU - Park, Hyun Jun AU - Park HJ FAU - Park, Nam Cheol AU - Park NC