• PMID: 20629646
• Gene Name: HMOX1
• Condition: Oligoasthenoteratozoospermia, varicocele
• Association: Associated
• Population size: 93
• Population details: 93 (healthy fertile controls (n = 34), OAT without varicocele (n = 37) and OAT associated with varicocele (n = 22))
• Sex: Male
• Infertility type: Male infertility
• Associated genes: HO
• Other associated phenotypes: Oligoasthenoteratozoospermia, varicocele

Heme oxygenase enzyme activity in seminal plasma of oligoasthenoteratozoospermic males with varicocele

Abdel Aziz MT, Mostafa T, Atta H, Kamal O, Kamel M, Hosni H, Rashed L, Sabry D, Waheed F.

This work aimed to assess seminal plasma heme oxygenase (HO) enzyme activity in oligoasthenoteratozoospermia (OAT) males with varicocele. Ninety-three men were divided according to their sperm count and clinical examination into: healthy fertile controls (n = 34), OAT without varicocele (n = 37) and OAT associated with varicocele (n = 22). They were subjected to semen analysis and estimation of seminal plasma HO enzyme activity in the form of bilirubin concentration. Seminal plasma HO enzyme activity decreased significantly in OAT cases compared with controls. Seminal plasma HO in OAT cases associated with varicocele decreased significantly compared with OAT cases without varicocele and healthy controls (mean +/- SD; 109.2 +/- 29.5, 283.6 +/- 88.4, 669.5 +/- 236.1 nMol bilirubin/mg ptn/min, P < 0.001). There was positive correlation between seminal plasma HO enzyme activity and sperm concentration, per cent of motile spermatozoa, number of motile spermatozoas ml(-1) and significant negative correlation with sperm abnormal forms per cent. It is concluded that varicocele has a negative impact on seminal HO enzyme activity. Therefore, improved seminal picture after correcting varicocele repair might be related, in part, to improved HO action(s). FAU - Abdel Aziz, M T AU - Abdel Aziz MT AD - Department of Medical Biochemistry, Molecular Biology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Mostafa, T AU - Mostafa T FAU - Atta, H AU - Atta H FAU - Kamal, O AU - Kamal O FAU - Kamel, M AU - Kamel M FAU - Hosni, H AU - Hosni H FAU - Rashed, L AU - Rashed L FAU - Sabry, D AU - Sabry D