• PMID: 20569797
• Gene Name: INSL3
• Condition: Cryptorchidism
• Association: Genetic and/or environmental factors that alter expression or function of hormones crucial for testicular descent, insulin-like 3, and testosterone, may contribute to cryptorchidism
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Cryptorchidism

Cryptorchidism: pathogenesis, diagnosis, treatment and prognosis

Ashley RA, Barthold JS, Kolon TF.

Cryptorchidism is a common genital anomaly diagnosed at birth or during childhood. Genetic and/or environmental factors that alter expression or function of hormones crucial for testicular descent, insulin-like 3, and testosterone, may contribute to cryptorchidism. When identified at birth, surgical treatment is indicated by 6 months of age if testes fail to descend, or at the time of diagnosis in older children. A laparoscopic approach is preferred for abdominal testes. Early surgical therapy may reduce the risk of subfertility and/or malignancy. FAU - Ashley, Richard A AU - Ashley RA AD - Nemours/Alfred I. DuPont Hospital for Children, Division of Pediatric Urology, Wilmington, DE 19803-3607, USA. FAU - Barthold, Julia S AU - Barthold JS