• PMID: 20524034
• Gene Name: KIF5C
• Condition: Involved in the redistribution of proteins during spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Involved in the redistribution of proteins during spermatogenesis

Protein kinase CK2 and new binding partners during spermatogenesis

Mannowetz N, Kartarius S, Wennemuth G, Montenarh M.

Protein kinase CK2 is an ubiquitously expressed enzyme that is absolutely necessary for the survival of cells. Besides the holoenzyme consisting of the regulatory β-subunit and the catalytic α- or α'-subunit, the subunits exist in separate forms. The subunits bind to a number of other cellular proteins. We show the expression of individual subunits as well as interaction with the transitional nuclear protein TNP1 and with the motor neuron protein KIF5C during spermatogenesis. TNP1 is a newly identified binding partner of the α-subunit of CK2. CK2α and KIF5C were found in late spermatogenesis, whereas CK2β and TNP1 were found in early spermatogenesis. CK2α, CK2α', TNP1, and KIF5C were detected in the acrosome of spermatozoa, while CK2β was detectable in the mid-piece. Combinations of CK2 subunits might determine interactions with other proteins during spermatogenesis. KIF5C as a kinesin motor neuron protein is probably involved in the redistribution of proteins during spermatogenesis. FAU - Mannowetz, Nadja AU - Mannowetz N AD - Department of Anatomy and Cell Biology, University of the Saarland, Homburg, Germany. FAU - Kartarius, Sabine AU - Kartarius S FAU - Wennemuth, Gunther AU - Wennemuth G