• PMID: 20231113
• Gene Name: IL6ST
• Condition: Asthenozoospermia
• Association: Associated
• Population size: 12
• Population details: 12 (6 healthy fertile men, 6 asthenozoospermia volunteers)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: annexin VI isoform 2, isoform 1 of interleukin-6 receptor subunit beta precursor, Mr 400,000 protein, cytosolic dynein heavy chain, alpha-actinin-4, receptor-type tyrosine-protein phosphatase eta precursor, vitamin D-binding protein precursor, protein S10
• Other associated phenotypes: Asthenozoospermia

Serum inhibin A concentration in women with polycystic ovarian syndrome and the correlation to ethnicity, androgens and insulin resistance

Segal S, Elmadjian M, Takeshige T, Karp S, Mercado R, Rivnay B.

A prospective case-series in an academic hospital clinic was performed to determine whether there is a relationship between polycystic ovarian syndrome (PCOS) and ethnicity. Also, serum inhibin A concentrations were compared between PCOS and normal-ovulatory women. The possibility of a correlation between inhibin A, androgens and insulin resistance in PCOS women was evaluated. Serum inhibin A concentrations were measured in anovulatory PCOS patients (n=32) and in control women of reproductive age (n=16). Statistical analysis was performed using the Mann-Whitney U-test. Serum concentrations of inhibin A, follicle-stimulating hormone, LH, prolactin, thyroid-stimulating hormone, fasting glucose, insulin, testosterone, 17-hydroxyprogesterone (17-OHP) and dehydroepiandrosterone sulphate (DHEAS) were measured. Inhibin A concentrations were significantly lower (4.5+/-4.8 pg/ml) when compared with the control group (13.2+/-14.4 pg/ml; P=0.003) and were not significantly different between Hispanic and Caucasian women diagnosed with PCOS. There was no correlation between inhibin A concentrations and insulin, testosterone, free testosterone, 17-OHP, or DHEAS concentrations. In PCOS women, inhibin A concentrations are similar between Hispanic and Caucasian women; however, women with PCOS, regardless of ethnicity, have a lower inhibin A concentration compared with normal-ovulatory women. No correlation was observed between inhibin A androgens and insulin resistance in women diagnosed with PCOS. CI - Copyright (c) 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. FAU - Segal, Shimon AU - Segal S AD - Division of Reproductive Medicine, Department of Obstetrics and Gynecology, 234-149th Street, Bronx, NY 10451, USA. ShimonSegal@aol.com FAU - Elmadjian, Malvina AU - Elmadjian M FAU - Takeshige, Takeko AU - Takeshige T FAU - Karp, Steven AU - Karp S FAU - Mercado, Ray AU - Mercado R