• PMID: 20188355
• Gene Name: COX-2
• Condition: Hypospermatogenesis, germ cell arrest or Sertoli cell-only syndrome
• Association: This study reports a positive correlation between IL-1? levels and COX-2 expression in testes of infertile patients, the induction of COX-2 by IL-1? in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore evidence for an IL-1?-dependent i
• Sex: Male
• Infertility type: Male infertility
• Associated genes: COX-2, IL- 1beta
• Other associated phenotypes: Hypospermatogenesis, germ cell arrest or Sertoli cell-only syndrome

Cyclooxygenase-2 in testes of infertile men: evidence for the induction of prostaglandin synthesis by interleukin-1?

Matzkin ME, Mayerhofer A, Rossi SP, Gonzalez B, Gonzalez CR, Gonzalez-Calvar SI, Terradas C, Ponzio R, Puigdomenech E, Levalle O, Calandra RS, Frungieri MB.

As we previously reported, testes of men suffering from hypospermatogenesis and germ cell arrest or Sertoli cell-only syndrome show a major increase in the number of macrophages expressing interleukin-1β (IL-1β) and abundant expression of cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the biosynthesis of prostaglandins (PGs), in Leydig cells. In the present study we report [1] a positive correlation between IL-1β levels and COX-2 expression in testes of infertile patients, [2] the induction of COX-2 by IL-1β in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore [3] evidence for an IL-1β-dependent induction of testicular inflammatory states. CI - Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. FAU - Matzkin, María Eugenia AU - Matzkin ME AD - Laboratorio de Esteroides, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina. FAU - Mayerhofer, Artur AU - Mayerhofer A FAU - Rossi, Soledad Paola AU - Rossi SP FAU - Gonzalez, Betina AU - Gonzalez B FAU - Gonzalez, Candela Rocío AU - Gonzalez CR FAU - Gonzalez-Calvar, Silvia Inés AU - Gonzalez-Calvar SI FAU - Terradas, Claudio AU - Terradas C FAU - Ponzio, Roberto AU - Ponzio R FAU - Puigdomenech, Elisa AU - Puigdomenech E FAU - Levalle, Oscar AU - Levalle O FAU - Calandra, Ricardo Saúl AU - Calandra RS