• PMID: 20056207
• Gene Name: GSTM1
• Condition: Idiopathic infertility
• Association: The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia.
• Population size: 430
• Population details: 430 (203 infertile, 227 fertile men)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: GSTM1, GSTT1
• Other associated phenotypes: Idiopathic infertility

The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men

Polonikov AV, Yarosh SL, Kokhtenko EV, Starodubova NI, Pakhomov SP, Orlova VS.

This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia. CI - Crown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved. FAU - Polonikov, Alexey V AU - Polonikov AV AD - Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia. polonikov@rambler.ru FAU - Yarosh, Sergey L AU - Yarosh SL FAU - Kokhtenko, Elena V AU - Kokhtenko EV FAU - Starodubova, Nina I AU - Starodubova NI FAU - Pakhomov, Sergey P AU - Pakhomov SP