• PMID: 19593987
• Gene Name: VDAC2
• Condition: Sperm motility
• Association: The decreased expression of VDAC2 in the ejaculated spermatozoa is possibly associated with the reduction of sperm motility.
• Sex: Male
• Infertility type: Male infertility
• Associated genes: VDAC1, VDAC2 and VDAC3
• Other associated phenotypes: Sperm motility

[Expression of the voltage-dependent anion channel gene in human ejaculated spermatozoa]

Xu X, Wang Y, Yu Z, Chen J, Guo M, Gui YT, Cai ZM.

OBJECTIVE: To identify the genes involved in sperm motility. METHODS: We hybridized asthenospermia and normal motile sperm cDNA samples with the human whole genome Affymetrix chip to screen differentially expressed genes. Then we detected the mRNA expressions of the voltage-dependent anion channel genes (VDACs) in human organs and spermatozoa by RT-PCR and compared their expressions in the poor and normal motility spermatozoa. RESULTS: Differentially expressed genes VDACs were identified by analysis of the hybridization signals, including the 3 subtypes VDAC1, VDAC2 and VDAC3. The expression of VDAC2 mRNA was significantly decreased in the poor motility sperm (0.568 +/- 0.036), as compared with the healthy men (0.803 +/- 0.043, P < 0.01). CONCLUSION: The decreased expression of VDAC2 in the ejaculated spermatozoa is possibly associated with the reduction of sperm motility. FAU - Xu, Xiang AU - Xu X AD - Key Laboratory of Male Reproductive and Genetic Medicine, Peking University Shenzhen Hospital, Shenzhen, Guang-dong 518036, China. xuxiang_hard@163.com FAU - Wang, Yong AU - Wang Y FAU - Yu, Zhou AU - Yu Z FAU - Chen, Jing AU - Chen J FAU - Guo, Meng AU - Guo M FAU - Gui, Yao-ting AU - Gui YT