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PMID 1908531
Gene Name SERPINE1
Condition Azoospermia, oligoasthenoteratozoospermia (OAT-syndrome)
Association In lysates of spermatozoas, significantly higher levels of both plasminogenactivators and PAI were found in patients with OAT syndrome as compared to those exhibiting normozoospermia.
Population size 67
Population details 67 (15 patients showed normozoospermia, 11 azoospermia, 41 oligoasthenoteratozoospermia (OAT-syndrome))
Sex Male
Infertility type Male infertility
Associated genes u-PA, t-PA, PAI
Other associated phenotypes Azoospermia, oligoasthenoteratozoospermia (OAT-syndrome)


Fibrinolytic parameters in spermatozoas and seminal plasma

Maier U, Kirchheimer JC, Hienert G, Christ G, Binder BR.

Urokinase-type (u-PA) and tissue-type plasminogen activator antigen (t-PA) as well as plasminogen activator-inhibitor activity were determined in seminal plasma and lysates of the respective spermatozoas in 67 ejaculate of males in infertile marriage without genito urinary pathology. U-PA was determined by a competition RIA, t-PA by an ELISA and PAI by a spectrophotometric assay. 15 patients showed normozoospermia, 11 azoospermia and 41 oligoasthenoteratozoospermia (OAT-syndrome). In lysates of spermatozoas, significantly higher levels of both plasminogenactivators and PAI were found in patients with OAT syndrome as compared to those exhibiting normozoospermia. Whereas PAI was absent in the seminal plasma of normozoospermic ejaculate, patients with azoospermia (180 +/- 13 mU/ml.) and OAT-syndrome (60 +/- 5 mU/ml.) showed high PAI levels. The similarly high values of t-PA (190.8-227.8 ng./ml.) and u-PA (19.4-32 ng./ml.) in the same compartment confirm their predominantly prostatic origin and seem to have no influence on the quality of the ejaculate. FAU - Maier, U AU - Maier U AD - Department of Urology, University of Vienna, Austria. FAU - Kirchheimer, J C AU - Kirchheimer JC FAU - Hienert, G AU - Hienert G FAU - Christ, G AU - Christ G