• PMID: 19006797
• Gene Name: FSH
• Condition: Male infertility, spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: Inhibin B, FSH
• Other associated phenotypes: Male infertility, spermatogenesis

Inhibin B reference data for fertile and infertile men in Northeast America

Myers GM, Lambert-Messerlian GM, Sigman M.

OBJECTIVE: To determine normative levels of inhibin B and examine levels in relationship to FSH, sperm count, and motility in a cohort of fertile and infertile men from the Northeast United States. DESIGN: Prospective comparative study of inhibin B levels in fertile and infertile patient groups. SETTING: Tertiary academic referral center. PATIENT(S): Fertile men were recruited among those presenting for elective vasectomy. Men being evaluated for infertility were also recruited within the same practice. INTERVENTION(S): Serum collection. MAIN OUTCOME MEASURE(S): FSH and inhibin B levels were measured in serum samples. RESULT(S): A total of 55 fertile and 85 presenting for infertility evaluations were recruited. The mean serum inhibin B level was significantly higher in the fertile (138 pg/mL) than infertile group (78 pg/mL). Inhibin B levels correlated positively (R(2) = 0.27) and FSH correlated negatively (R(2) = 0.33) with total sperm concentration. General linear model multiple regression demonstrated that the FSH and inhibin B were equally predictive of sperm concentration. CONCLUSION(S): Inhibin B levels in fertile men and infertile men in Northeast America were similar but not identical to those reported in other geographic regions. Both inhibin B and FSH are useful markers of spermatogenesis. FAU - Myers, Gavin M AU - Myers GM AD - The Alpert Medical School of Brown University, Providence, Rhode Island, USA. FAU - Lambert-Messerlian, Geralyn M AU - Lambert-Messerlian GM