• PMID: 18774560
• Gene Name: CYP1A1
• Condition: Male factor infertility
• Association: There were significant differences between infertility and GSTM1, CYP1A1(*)2C genotypes by univariate analyses. A subject carrying CYP1A1 Val/Val or CYP1A1 Ile/Val in association with GSTM null genotype has 6.90 times more risk to be infertile than a subj
• PMID: 18774560
• Gene Name: CYP1A1
• Condition: Male factor infertility
• Association: There were significant differences between infertility and GSTM1, CYP1A1(*)2C genotypes by univariate analyses. A subject carryingCYP1A1 Val/Val or CYP1A1 Ile/Val in association with GSTM null genotype has 6.90 times more risk to be infertile than a subje
• Population size: 215
• Population details: 215 (110 men with infertility, 105 healthy fertile men)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male factor infertility

Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility

Aydos SE, Taspinar M, Sunguroglu A, Aydos K.

OBJECTIVE: To examine whether a relationship exists between genetic polymorphisms of glutathione S-transferase (GST) M1 and T1, CYP1A1(*)2C, and male factor infertility. DESIGN: Genetic polymorphism analysis, case-control study. SETTING: University research laboratory and andrology clinic. PATIENT(S): One hundred ten men with infertility and 105 healthy fertile men were recruited for the study. INTERVENTION(S): Physical examination of the genitalia of patients, scrotal colored Doppler ultrasound examination, and blood sampling were performed for DNA extraction and genotyping. MAIN OUTCOME MEASURE(S): CYP1A1(*)2C, GSTM1, and GSTT1 polymorphism genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism methods. Seminal parameters were analyzed. RESULT(S): There were significant differences between infertility and GSTM1, CYP1A1(*)2C genotypes by univariate analyses. A subject carrying CYP1A1 Val/Val or CYP1A1 Ile/Val in association with GSTM null genotype has 6.90 times more risk to be infertile than a subject carrying CYP1A1 Ile/Ile in association with GSTM1 wild-type genotype (odds ratio: 6.90, 95% confidence interval: 2.29-19.3). No correlation was found between the seminal parameters and the genetic variability. CONCLUSION: Our results suggest that genetic polymorphisms of xenobiotic-metabolizing enzymes could play an important role in infertility. FAU - Aydos, Sena Erdogan AU - Aydos SE AD - Department of Medical Biology, Faculty of Medicine, Ankara University, Ankara, Turkey. FAU - Taspinar, Mehmet AU - Taspinar M FAU - Sunguroglu, Asuman AU - Sunguroglu A