• PMID: 18676362
• Gene Name: AR
• Condition: Spermatogenetic defects, Male infertility
• Association: The results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertilit
• Mutation: CAG repeat length
• Population size: 122
• Population details: 122 (82 infertile, 40 controls )
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Spermatogenetic defects, Male infertility

Genetic screening in infertile Mexican men: chromosomal abnormalities, Y chromosome deletions, and androgen receptor CAG repeat length

Martínez-Garza SG, Gallegos-Rivas MC, Vargas-Maciel M, Rubio-Rubio JM, de Los Monteros-Rodríguez ME, González-Ortega C, Cancino-Villarreal P, de Lara LG, Gutiérrez-Gutiérrez AM.

In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility. FAU - Martínez-Garza, Sandra Guadalupe AU - Martínez-Garza SG AD - Instituto de Ciencias en Reproducción Humana Vida (Instituto Vida), Plaza Las Américas 115, Col Jardines del Moral, León, Guanajuato, México CP 37160. samartin30@yahoo.com FAU - Gallegos-Rivas, Mayra Celina AU - Gallegos-Rivas MC FAU - Vargas-Maciel, Marcos AU - Vargas-Maciel M FAU - Rubio-Rubio, Juan Manuel AU - Rubio-Rubio JM FAU - de Los Monteros-Rodríguez, Mario Espinosa AU - de Los Monteros-Rodríguez ME FAU - González-Ortega, Claudia AU - González-Ortega C FAU - Cancino-Villarreal, Patricia AU - Cancino-Villarreal P FAU - de Lara, Luis G Vazquez AU - de Lara LG