• PMID: 18367176
• Gene Name: CAB39L
• Condition: Male infertility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: Microarray

Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome

Garrido N, Mart�nez-Conejero JA, Jauregui J, Horcajadas JA, Sim�n C, Remoh� J, Meseguer M.

Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynecologic pathology. Consequently, there is a need for accurate diagnostic tools in this area, and microarray technology emerges as promising. We present, for the first time, preliminary results of a comparison of sperm mRNA expression profiles between fertile and infertile men with normal semen parameters, discovering profound discrepancies between groups, with potential diagnostic and therapeutic possibilities. FAU - Garrido, N AU - Garrido N AD - Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain. nicolas.garrido@ivi.es FAU - Martínez-Conejero, J A AU - Martínez-Conejero JA FAU - Jauregui, J AU - Jauregui J FAU - Horcajadas, J A AU - Horcajadas JA FAU - Simón, C AU - Simón C FAU - Remohí, J AU - Remohí J