• PMID: 18367176
• Gene Name: TGM4
• Condition: Male infertility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: Microarray

Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome

Garrido N, Martínez-Conejero JA, Jauregui J, Horcajadas JA, Simón C, Remohí J, Meseguer M.

Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynecologic pathology. Consequently, there is a need for accurate diagnostic tools in this area, and microarray technology emerges as promising. We present, for the first time, preliminary results of a comparison of sperm mRNA expression profiles between fertile and infertile men with normal semen parameters, discovering profound discrepancies between groups, with potential diagnostic and therapeutic possibilities. FAU - Garrido, N AU - Garrido N AD - Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain. nicolas.garrido@ivi.es FAU - Martínez-Conejero, J A AU - Martínez-Conejero JA FAU - Jauregui, J AU - Jauregui J FAU - Horcajadas, J A AU - Horcajadas JA FAU - Simón, C AU - Simón C FAU - Remohí, J AU - Remohí J