• PMID: 18321497
• Gene Name: AMH
• Condition: Azoospermia
• Association: Serum INHB and AMH, as well as their combination, are not superior to FSH as predictors of the presence of sperm in testicular FNA in men with azoospermia and should not be used for this purpose.
• Population size: 82
• Population details: 82 (51 men with azoospermia, 31 controls)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: FSH, INHB, AMH
• Other associated phenotypes: Azoospermia

Serum inhibin B and anti-Müllerian hormone are not superior to follicle-stimulating hormone as predictors of the presence of sperm in testicular fine-needle aspiration in men with azoospermia

Goulis DG, Tsametis C, Iliadou PK, Polychronou P, Kantartzi PD, Tarlatzis BC, Bontis IN, Papadimas I.

OBJECTIVE: To compare FSH, inhibin B (INHB), and anti-Müllerian hormone (AMH) as predictors of the recovery of sperm in testicular fine-needle aspiration biopsy (FNA) performed in men with azoospermia. DESIGN: Cross-sectional, clinical study. SETTING: Academic Unit of Reproductive Endocrinology. PATIENT(S): Fifty-one men with azoospermia and 31 controls. INTERVENTION(S): Testicular FNA. MAIN OUTCOME MEASURE(S): Serum FSH, INHB, and AMH levels. RESULT(S): Clinical diagnoses in men with azoospermia were idiopathic nonobstructive azoospermia (n = 34, 67%), cryptorchidism (n = 4, 8%), varicocele (n = 3, 6%), and other diagnoses (n = 10, 16%). In pairwise comparison of receiver operating characteristic curves, none of FSH (area under curve 0.716), INHB (0.610), AMH (0.565), or volume of the larger testis (0.693) was proved to be superior to the others as predictor of sperm retrieval during an FNA procedure. Similarly, in a logistic regression analysis, none of FSH, AMH, INHB, or volume of the larger testis could predict presence of sperm in FNA. CONCLUSION(S): Serum INHB and AMH, as well as their combination, are not superior to FSH as predictors of the presence of sperm in testicular FNA in men with azoospermia and should not be used for this purpose. FAU - Goulis, Dimitrios G AU - Goulis DG AD - First Department of Obstetrics and Gynecology, Unit of Reproductive Endocrinology, Aristotle University of Thessaloniki, Thessaloniki, Greece. dimitrios.goulis@otenet.gr FAU - Tsametis, Christos AU - Tsametis C FAU - Iliadou, Paschalia K AU - Iliadou PK FAU - Polychronou, Paris AU - Polychronou P FAU - Kantartzi, Persefoni-Dimitra AU - Kantartzi PD FAU - Tarlatzis, Basil C AU - Tarlatzis BC FAU - Bontis, Ioannis N AU - Bontis IN