• PMID: 18283110
• Gene Name: TEX15
• Condition: TEX15-deficient spermatocytes exhibit a failure in chromosomal synapsis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: TEX15-deficient spermatocytes exhibit a failure in chromosomal synapsis

Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis

Yang F, Eckardt S, Leu NA, McLaughlin KJ, Wang PJ.

During meiosis, homologous chromosomes undergo synapsis and recombination. We identify TEX15 as a novel protein that is required for chromosomal synapsis and meiotic recombination. Loss of TEX15 function in mice causes early meiotic arrest in males but not in females. Specifically, TEX15-deficient spermatocytes exhibit a failure in chromosomal synapsis. In mutant spermatocytes, DNA double-strand breaks (DSBs) are formed, but localization of the recombination proteins RAD51 and DMC1 to meiotic chromosomes is severely impaired. Based on these data, we propose that TEX15 regulates the loading of DNA repair proteins onto sites of DSBs and, thus, its absence causes a failure in meiotic recombination. FAU - Yang, Fang AU - Yang F AD - Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. FAU - Eckardt, Sigrid AU - Eckardt S FAU - Leu, N Adrian AU - Leu NA FAU - McLaughlin, K John AU - McLaughlin KJ