• PMID: 18163994
• Gene Name: GSTT1
• Condition: Varicocele
• Association: The results show that oxidative damage may be the cause of infertility in patients with varicocele, and GSTT1 null genotype predisposes to over oxidative damage to spermatocytes of infertile patients with varicocele.
• Population size: 117
• Population details: 117 (63 infertile patients with varicocele, 54 healthy fertile controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Varicocele

Influence of polymorphism of glutathione S-transferase T1 on Chinese infertile patients with varicocele

Wu Q, Xing J, Xue W, Sun J, Wang X, Jin X.

To investigate the influence of glutathione S-transferase T1 (GSTT1) gene polymorphism on Chinese infertile patients with varicocele, 63 infertile patients with varicocele and 54 healthy fertile controls were recruited in this case-control study. Our results show that oxidative damage may be the cause of infertility in patients with varicocele, and GSTT1 null genotype predisposes to over oxidative damage to spermatocytes of infertile patients with varicocele. FAU - Wu, Qifei AU - Wu Q AD - Department of Urology, First Affiliated Hospital, School of Medicine, Xi'an Jiao Tong University, Xi'an City, ShannXi Province, People's Republic of China. FAU - Xing, Junping AU - Xing J FAU - Xue, Wei AU - Xue W FAU - Sun, Jianhua AU - Sun J FAU - Wang, Xinyang AU - Wang X