• PMID: 18097510
• Gene Name: GSTT1
• Condition: Idiopathic azoospermia or oligospermia
• Association: GSTT1 null genotype is a predisposing risk factor for sporadic idiopathic azoospermia or oligospermia in northwestern China.
• Population size: 337
• Population details: 337 (78 patients with idiopathic azoospermia, 103 patients with idiopathic oligospermia, 156 age-matched controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Idiopathic azoospermia or oligospermia

Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China

Wu QF, Xing JP, Tang KF, Xue W, Liu M, Sun JH, Wang XY, Jin XJ.

AIM: To investigate the association of glutathione S-transferase T1 (GSTT1) gene polymorphism in patients with idiopathic azoospermia or oligospermia in the northwestern China population. METHODS: In the case-control study, GSTT1 genotypes were identified by multiplex polymerase chain reaction (PCR) with peripheral blood DNA samples from 78 patients with idiopathic azoospermia, 103 patients with idiopathic oligospermia and 156 age-matched controls with normal sperm concentration and motility, according to the criteria adapted from World Health Organization guidelines. All of the patients and controls were from northwestern China. RESULTS: There is a significant association between GSTT1 null genotype with idiopathic azoospermia risk (odds ratio [OR]: 2.36, 95% confidence interval [CI]: 1.33-4.20, P=0.003) or idiopathic oligospermia risk (OR: 2.00, 95% CI: 1.17-3.27, P=0.010). CONCLUSION: GSTT1 null genotype is a predisposing risk factor for sporadic idiopathic azoospermia or oligospermia in northwestern China. FAU - Wu, Qi-Fei AU - Wu QF AD - Department of Urology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Xing, Jun-Ping AU - Xing JP FAU - Tang, Kai-Fa AU - Tang KF FAU - Xue, Wei AU - Xue W FAU - Liu, Min AU - Liu M FAU - Sun, Jian-Hua AU - Sun JH FAU - Wang, Xin-Yang AU - Wang XY