• PMID: 17926161
• Gene Name: AMH
• Condition: Male subfertility, idiopathic non-obstructive azoospermia, idiopathic non-obstructive dyspermia, varicocele, cryptorchidism
• Association: Serum AMH levels differentiate control from subfertile men but not men with different causes of subfertility
• Population size: 113
• Population details: 113 (82 subfertile men, 31 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male subfertility, idiopathic non-obstructive azoospermia, idiopathic non-obstructive dyspermia, varicocele, cryptorchidism

Serum anti-Müllerian hormone levels differentiate control from subfertile men but not men with different causes of subfertility

Goulis DG, Iliadou PK, Tsametis C, Gerou S, Tarlatzis BC, Bontis IN, Papadimas I.

AIM: To determine stimulated serum anti-Mllerian hormone (AMH) levels in men with different causes of subfertility. SUBJECTS AND METHODS: We prospectively studied 82 subfertile men and 31 controls. The subfertile men underwent a diagnostic procedure to identify the causes of subfertility. Study parameters included testicular volume, levels of follicle-stimulating hormone, luteinizing hormone, total testosterone, prolactin, inhibin B and AMH, and sperm parameters. RESULTS: Clinical diagnoses in subfertile men were idiopathic non-obstructive azoospermia (n = 26, 32%), idiopathic non-obstructive dyspermia (n = 17, 21%), varicocele (n = 16, 20%), cryptorchidism (n = 10, 12%) and other diagnoses (n = 13, 16%). Serum AMH levels in subfertile men were 60% lower than in controls [median (interquartile range) 4.6 (3.6) vs. 11.6 (7.7) ng/ml, p 0.001], with no significant differences among the different groups of subfertile men. CONCLUSIONS: Serum AMH levels differentiate control from subfertile men but not men with different causes of subfertility. FAU - Goulis, Dimitrios G AU - Goulis DG AD - Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece. dimitrios.goulis@otenet.gr FAU - Iliadou, Paschalia K AU - Iliadou PK FAU - Tsametis, Christos AU - Tsametis C FAU - Gerou, Spyridon AU - Gerou S FAU - Tarlatzis, Basil C AU - Tarlatzis BC FAU - Bontis, Ioannis N AU - Bontis IN