• PMID: 17889867
• Gene Name: AR
• Condition: Spermatogenic failure
• Association: This study shows that there is no association between CAG repeat length variation and semen quality
• Mutation: CAG repeat length variation
• Population size: 226
• Population details: 226 (153 infertile men, 73 proven fertile controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Spermatogenic failure

CAG repeat length variation in the androgen receptor gene is not associated with spermatogenic failure

Westerveld H, Visser L, Tanck M, van der Veen F, Repping S.

Previous association studies that described the effect of an enlarged CAG repeat length in the Androgen Receptor (AR) gene on spermatogenesis could not prove or refute a true association because of methodological weaknesses. Here, we clearly show that there is no association between CAG repeat length variation and semen quality. FAU - Westerveld, Henrike AU - Westerveld H AD - Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, the Netherlands. g.h.westerveld@amc.uva.nl FAU - Visser, Liesbeth AU - Visser L FAU - Tanck, Michael AU - Tanck M FAU - van der Veen, Fulco AU - van der Veen F