• PMID: 17714215
• Gene Name: LEP
• Condition: Oligozoospermia, Male infertility
• Association: Serum leptin demonstrated significant positive correlation with age, body weight, BMI and significant inverse correlation with serum testosterone. It had nonsignificant correlation with the height and sperm concentration.
• Population size: 80
• Population details: 80 (30 fertile normozoospermia as a control, 50 infertile oligozoospermia)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Oligozoospermia, Male infertility

Serum leptin correlates in infertile oligozoospermic males

Hanafy S, Halawa FA, Mostafa T, Mikhael NW, Khalil KT.

Leptin is an adipocyte-secreted protein that participates in the regulation of energy homeostasis. Eighty men were investigated; fertile normozoospermia as a control (n = 30) and infertile oligozoospermia (n = 50). The patients underwent estimation of body weight (kg), height (cm), calculation of body mass index (BMI), semen analysis, serum leptin and testosterone hormones. Mean body weight was significantly higher in infertile oligozoospermia compared with controls. Mean height, BMI and serum testosterone levels showed nonsignificant differences between the two groups. Infertile oligozoospermia had significantly higher mean serum leptin level than controls (mean +/- SD; 6.88 +/- 8.65, 16.3 +/- 13.98 ng ml(-1), P < 0.01). Serum leptin demonstrated significant positive correlation with age, body weight, BMI and significant inverse correlation with serum testosterone. It had nonsignificant correlation with the height and sperm concentration. These results are suggestive of a link between the adipocyte derived hormone, leptin and male reproduction. FAU - Hanafy, S AU - Hanafy S AD - Dermatology & Andrology Department, Faculty of Medicine, Benha University, Benha, Egypt. FAU - Halawa, F A AU - Halawa FA FAU - Mostafa, T AU - Mostafa T FAU - Mikhael, N W AU - Mikhael NW