• PMID: 17668444
• Gene Name: JAKMIP1
• Condition: Associates to the cytoskeleton and GABAB receptors in mammalian testis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Associates to the cytoskeleton and GABAB receptors in mammalian testis

Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors

Vidal RL, Ramírez A, Castro M, Concha II, Couve A.

Marlin-1 is a GABA(B) receptor and Jak tyrosine kinase-binding protein that also associates with RNA and microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression in lymphoid cells has also been reported. Here, we have studied the distribution of Marlin-1 in testis and spermatozoa. Our results indicate that Marlin-1 is highly expressed in testis. The protein is abundant in spermatogonia, spermatocytes, spermatozoa, and Sertoli cells. We also have studied the subcellular distribution in spermatozoa. Marlin-1 is present in the tail and to a lesser degree in the head of the sperm cell. Finally, we have explored two protein interactions. Our findings demonstrate that Marlin-1 associates with a microtubule fraction and with GABA(B) receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues. CI - Copyright 2007 Wiley-Liss, Inc. FAU - Vidal, René L AU - Vidal RL AD - Institute of Biochemistry, Universidad Austral de Chile, Isla Teja, Valdivia, Chile. FAU - Ramírez, Alfredo AU - Ramírez A FAU - Castro, Maite AU - Castro M FAU - Concha, Ilona I AU - Concha II