• PMID: 17592555
• Gene Name: MIF
• Condition: Sperm maturation and motility, Male infertility
• Association: The study reveals a correlation between MIF levels in human seminal fluid and fertility status. We identify an abnormal biphasic profile of MIF in the seminal fluid of patients with impaired sperm parameters.
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Sperm maturation and motility, Male infertility

Imbalance in seminal fluid MIF indicates male infertility

Aljabari B, Calogero AE, Perdichizzi A, Vicari E, Karaki R, Lahloub T, Zatari R, El-Abed K, Nicoletti F, Miller EJ, Pavlov VA, Al-Abed Y.

Macrophage migration inhibitory factor (MIF) is a ubiquitous cytokine that functions in reproduction and plays an important role in sperm maturation and motility. Here we reveal a correlation between MIF levels in human seminal fluid and fertility status. We identify an abnormal biphasic profile of MIF in the seminal fluid of patients with impaired sperm parameters. Our findings may be of interest for the development of a diagnostic method for fertility status. FAU - Aljabari, Bayan AU - Aljabari B AD - Laboratory of Medicinal Chemistry, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA. FAU - Calogero, Aldo E AU - Calogero AE FAU - Perdichizzi, Anna AU - Perdichizzi A FAU - Vicari, Enzo AU - Vicari E FAU - Karaki, Raja AU - Karaki R FAU - Lahloub, Tarek AU - Lahloub T FAU - Zatari, Rashed AU - Zatari R FAU - El-Abed, Khaleel AU - El-Abed K FAU - Nicoletti, Ferdinando AU - Nicoletti F FAU - Miller, Edmund J AU - Miller EJ FAU - Pavlov, Valentin A AU - Pavlov VA