• PMID: 17491259
• Gene Name: FASLG
• Condition: Idiopathic azoospermia, severe oligozoospermia
• Association: FASL-844 polymorphism appears to be a genetic predisposing factor of idiopathic azoospermia or severe oligozoospermia among southern Chinese Han males.
• Mutation: FASL-844 CT and TT genotypes
• Population size: 420
• Population details: 420 (184 infertile patients with idiopathic azoospermia or severe oligozoospermia, 236 normal fertile male controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Idiopathic azoospermia, severe oligozoospermia

[Association of FASL-844 polymorphism with the risk of idiopathic azoospermia and severe oligozoospermia]

Wang W, Lu NX, Xia YA, Wang XR, Zhang W, Song NH, Wei M, Su JT.

OBJECTIVE: To study the distribution of FASL-844 polymorphism in southern Chinese males of Han nationality and examine the contribution of the polymorphism to susceptibility of idiopathic azoospermia and oligozoospermia. METHODS: FASL-844 polymorphism was genotyped by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) in 184 infertile patients with idiopathic azoospermia or severe oligozoospermia 236 normal fertile male controls. RESULTS: Frequencies of FASL-844 CT and TT genotypes of the patients were significantly different from those of the controls (P = 0.024; P = 0.008). Males with FASL-844 TT genotype had an increased risk of idiopathic azoospermia or severe oligozoospermia compared with those with CC genotype (OR 2.76, 95% CI: 1.20-6.35), and even a higher risk when compared with those with CC and CT genotypes (OR 2.90, 95% CI: 1.28-6.58). CONCLUSION: FASL-844 polymorphism appears to be a genetic predisposing factor of idiopathic azoospermia or severe oligozoospermia among southern Chinese Han males. FAU - Wang, Wei AU - Wang W AD - Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Institute of Applied Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China. FAU - Lu, Ning-xia AU - Lu NX FAU - Xia, Yan-ai AU - Xia YA FAU - Wang, Xin-ru AU - Wang XR FAU - Zhang, Wei AU - Zhang W FAU - Song, Ning-hong AU - Song NH FAU - Wei, Min AU - Wei M